Presenter Information

Johanna LasiterFollow

Presenter Educational Level

undergraduate

Department

Department of Chemistry

Presentation Type

Panel Discussion

Start Date

20-3-2021 11:30 AM

Abstract

Neglected Tropical Diseases (NTDs) pose an enormous threat to those in poverty-stricken regions of the world such as Central and South America. NTDs have affected the lives of nearly 2 billion people worldwide. With limited funds and resources, research on NTDs is lacking.

Chagas disease, one such NTD, is a parasitic infection that is now becoming widespread throughout the southwest United States. Chagas disease is caused by the parasite, Trypanosoma cruzi, carried by an insect known as the “kissing bug”. Once infected, the insect passes parasites through their feces and can eventually cause “Chagas heart disease,” resulting in death.

There are currently two drugs in the market for treating Chagas, benznidazole and nifurtimox. Benznidazole is the only drug of the two that is FDA-approved, and both drugs have severe side effects along with alarming reports of treatment failures due to drug resistance in T. cruzi. We aim to make a new class of anti-Chagastic compounds using disquaramide structural motifs. Disquaramides have shown to have anti-parasitic activity and are facile and cost-efficient to synthesize. The main focus of this research is to create inexpensive drugs to aid in the fight against Chagas disease.

Keywords

Chagas, NTD, Trypanosoma Cruzi, Benznidazole

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Mar 20th, 11:30 AM

An inexpensive and efficient approach to cure Chagas Disease

Neglected Tropical Diseases (NTDs) pose an enormous threat to those in poverty-stricken regions of the world such as Central and South America. NTDs have affected the lives of nearly 2 billion people worldwide. With limited funds and resources, research on NTDs is lacking.

Chagas disease, one such NTD, is a parasitic infection that is now becoming widespread throughout the southwest United States. Chagas disease is caused by the parasite, Trypanosoma cruzi, carried by an insect known as the “kissing bug”. Once infected, the insect passes parasites through their feces and can eventually cause “Chagas heart disease,” resulting in death.

There are currently two drugs in the market for treating Chagas, benznidazole and nifurtimox. Benznidazole is the only drug of the two that is FDA-approved, and both drugs have severe side effects along with alarming reports of treatment failures due to drug resistance in T. cruzi. We aim to make a new class of anti-Chagastic compounds using disquaramide structural motifs. Disquaramides have shown to have anti-parasitic activity and are facile and cost-efficient to synthesize. The main focus of this research is to create inexpensive drugs to aid in the fight against Chagas disease.