Presentation Type
Panel Discussion
Start Date
20-3-2021 11:30 AM
Abstract
Herein, we describe a carrier-free combination nanodrug for treatment of cancer. In this work, we combined a photothermal compound and a chemotherapeutic drug using ionic liquid chemistry. We utilized a facile, one-step metathesis approach to replace the counter cation of a near infra-red (NIR) dye (photothermal agent) with a chemotherapeutic cation to synthesize an ionic material-based combination cancer therapy drug to deliver multiple mechanisms simultaneously. The nanodrugs were developed by using a reprecipitation method. The detailed photophysical properties of this new combination therapy molecule was investigated in ethanol solution as well as in nanoparticles forms in aqueous media. The singlet oxygen quantum yield and the light to heat conversion efficiency of the photothermal dyes were shown to be enhanced in combination nanodrugs. The dark and light cytotoxicity of the combination nanomedicine was investigated in vitro in the human breast cancer cell line (MCF-7). The ionic nanodrugs exhibited an improved dark and light cytotoxicity than either the chemotherapeutic or photothermal parent compounds individually, due to a synergistic effect of the combined therapies and nanoparticle formation.
Keywords
ionic liquids, photothermal therapy, nanoparticles, photodynamic therapy
Carrier-free Chemo-PTT/PDT ionic nanomaterials for combination cancer therapy
Herein, we describe a carrier-free combination nanodrug for treatment of cancer. In this work, we combined a photothermal compound and a chemotherapeutic drug using ionic liquid chemistry. We utilized a facile, one-step metathesis approach to replace the counter cation of a near infra-red (NIR) dye (photothermal agent) with a chemotherapeutic cation to synthesize an ionic material-based combination cancer therapy drug to deliver multiple mechanisms simultaneously. The nanodrugs were developed by using a reprecipitation method. The detailed photophysical properties of this new combination therapy molecule was investigated in ethanol solution as well as in nanoparticles forms in aqueous media. The singlet oxygen quantum yield and the light to heat conversion efficiency of the photothermal dyes were shown to be enhanced in combination nanodrugs. The dark and light cytotoxicity of the combination nanomedicine was investigated in vitro in the human breast cancer cell line (MCF-7). The ionic nanodrugs exhibited an improved dark and light cytotoxicity than either the chemotherapeutic or photothermal parent compounds individually, due to a synergistic effect of the combined therapies and nanoparticle formation.