Presentation Type
Poster
Department
Chemistry
Location
Walker Conference Center B
Description
Photodynamic therapy is a new technique used in cancer treatment involving the use of a photosensitizer and light exposure to kill malignant cells. This research tested the use of ZnTPP-2MP as a photosensitizer using white light as a source of possible treatment of the A549 cancer cell line, with preliminary testing on MYC-22 and other G- quadruplex DNA samples. ZnTPP-2MP was synthesized by the reaction of the porphyrin, ZnTPPC, with 2-amino-2- methyl-1-propanol. Following synthesis, the new porphyrin was purified by column chromatography using Sephadex LH-20 and G-50. To confirm the identity and structure of the product, ZnTPP-2MP was analyzed through nuclear magnetic resonance (NMR), infrared (IR), ultraviolet-visible (UV-vis) and fluorescence spectroscopies. Purity of the final compound was determined using HPLC. Additionally, ROS (reactive oxygen species) production using the novel porphyrin, is currently being tested.
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Included in
The Development of a New Water-Soluble Zinc Porphyrin, ZnTPP-2MP, as a Photodynamic Therapy Agent
Walker Conference Center B
Photodynamic therapy is a new technique used in cancer treatment involving the use of a photosensitizer and light exposure to kill malignant cells. This research tested the use of ZnTPP-2MP as a photosensitizer using white light as a source of possible treatment of the A549 cancer cell line, with preliminary testing on MYC-22 and other G- quadruplex DNA samples. ZnTPP-2MP was synthesized by the reaction of the porphyrin, ZnTPPC, with 2-amino-2- methyl-1-propanol. Following synthesis, the new porphyrin was purified by column chromatography using Sephadex LH-20 and G-50. To confirm the identity and structure of the product, ZnTPP-2MP was analyzed through nuclear magnetic resonance (NMR), infrared (IR), ultraviolet-visible (UV-vis) and fluorescence spectroscopies. Purity of the final compound was determined using HPLC. Additionally, ROS (reactive oxygen species) production using the novel porphyrin, is currently being tested.