Comparative Analysis of Drug Inclusion Techniques in Nanofiber Mats
Presentation Type
Thesis
Department
Biology
Location
Walker Conference Center A
Description
Drug inclusion in fiber mats is an important aspect of modern wound dressings for healing assistance. Through the infusion of drug molecules in modern bandages, dressings can be loaded with compounds that fight infection and hasten the healing process. Therapeutics are typically infused into nanofibrous mats via electrospinning a solution of a polymer mixed with a drug molecule. While this technique is an effective means of incorporating drugs into constructs, it limits the application of the resulting mats to conditions that call for that specific therapeutic. Alternatively, dipping polymer nanofiber mats into therapeutic-containing solutions is another way drugs could be infused into materials that could prove to be an alternate and more accessible infusion method. The objective of this research is to compare the drug release from electrospun nanofiber mats using two different methods of infusion: dipping and electrospinning. The hypothesis of these preliminary studies is that therapeutic-dipped fiber mats will give a similar drug release profile to that of therapeuticelectrospun fiber mats proving the dipping method of drug infusion can be an equitable and flexible alternative to. the current electrospining method of infusing drugs.
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Comparative Analysis of Drug Inclusion Techniques in Nanofiber Mats
Walker Conference Center A
Drug inclusion in fiber mats is an important aspect of modern wound dressings for healing assistance. Through the infusion of drug molecules in modern bandages, dressings can be loaded with compounds that fight infection and hasten the healing process. Therapeutics are typically infused into nanofibrous mats via electrospinning a solution of a polymer mixed with a drug molecule. While this technique is an effective means of incorporating drugs into constructs, it limits the application of the resulting mats to conditions that call for that specific therapeutic. Alternatively, dipping polymer nanofiber mats into therapeutic-containing solutions is another way drugs could be infused into materials that could prove to be an alternate and more accessible infusion method. The objective of this research is to compare the drug release from electrospun nanofiber mats using two different methods of infusion: dipping and electrospinning. The hypothesis of these preliminary studies is that therapeutic-dipped fiber mats will give a similar drug release profile to that of therapeuticelectrospun fiber mats proving the dipping method of drug infusion can be an equitable and flexible alternative to. the current electrospining method of infusing drugs.
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