Presentation Type
Poster
Department
Chemistry
Description
Photodynamic therapy (PDT) has potential use in the treatment of cancer and other health disorders. PDT utilizes light and a photosensitive agent that once activated by light generates singlet oxygen that affects surrounding cells. Metalloporphyrins have been shown to accumulate in tumors as the result of preferential binding to low-density lipoproteins. Additionally, gallium(III) porphyrins have been shown to be effective potential photosensitizers for PDT. The goal of this research was to synthesize and characterize the novel photosensitive agent, GaTPP-DIPA, as a PDT agent. The GaTPP-DIPA was purified using column chromatography and characterized using IR, UV-Vis, and NMR spectroscopies, purity was determined using HPLC. Cytotoxicity testing of the GaTPP-DIPA using U87 glioblastoma cells in both light and dark conditions determined that novel material has potential as a next generation PDT agent.
Presentation Audio
Included in
The Photodynamic Therapy Potential of a Novel Water Soluble Gallium Porphyrin
Photodynamic therapy (PDT) has potential use in the treatment of cancer and other health disorders. PDT utilizes light and a photosensitive agent that once activated by light generates singlet oxygen that affects surrounding cells. Metalloporphyrins have been shown to accumulate in tumors as the result of preferential binding to low-density lipoproteins. Additionally, gallium(III) porphyrins have been shown to be effective potential photosensitizers for PDT. The goal of this research was to synthesize and characterize the novel photosensitive agent, GaTPP-DIPA, as a PDT agent. The GaTPP-DIPA was purified using column chromatography and characterized using IR, UV-Vis, and NMR spectroscopies, purity was determined using HPLC. Cytotoxicity testing of the GaTPP-DIPA using U87 glioblastoma cells in both light and dark conditions determined that novel material has potential as a next generation PDT agent.