Preparation and Analysis of Imine-Conjugate Amoxicillin Chitosan Hydrogels for Wound Care Applications

Date of Award

5-8-2025

Document Type

Thesis

Department

Chemistry

First Reader

Dr. Sharon Hamilton

Second Reader

Dr. Angela Douglass

Third Reader

Dr. Adam Jones

Abstract

In the past decade, research has shown the effectiveness of biopolymers for medical applications such as wound dressing, suturing, promoting cell proliferation, and controlled drug administration (Baranwal et al., 2022). Chitosan is a natural biopolymer of high functionality that is comprised of repeating β-(1,4)-2-amino-D-glucose and β-(1,4)-2-acetamido-D-glucose units that are linked by 1,4-β-glycosidic bonds. Chitosan is a highly biocompatible, cost effective, and versatile biopolymer that has merit in several medical applications, including hydrogels (Nicolle et al.,) Due to Chitosan’s large number of functional groups, it is possible to functionalize the polymer with antibiotic and therapeutic compounds through a reversible mechanism. This study explores the effectiveness of chitosan functionalization for drug delivery for wound care. It is possible to functionalize the chitosan at primary alcohol groups with primary amine containing drugs, which includes many antibiotics like amoxicillin, so that they can later be released at the wound site for therapeutic effects. The functionalized chitosan would retain its cross-linking capabilities and allow for comparison of effective drug delivery between an antibiotic functionalized chitosan hydrogel and a traditional antibiotic loaded chitosan hydrogel.

Comments

The research for this presentation was done in cooperation with Dr. Sharon Hamilton. The presentation is embargoed until May 2029.

This document is currently not available here.

Plum Print visual indicator of research metrics
PlumX Metrics
  • Usage
    • Abstract Views: 1
see details

Share

COinS