Date of Award
4-13-2021
Document Type
Thesis
Department
Biology
First Reader
Dr. Tim Knight
Second Reader
Dr. Jim Taylor
Third Reader
Dr. Scott Duvall
Abstract
Glioblastoma is a malignant brain tumor without effective treatment options available because of its resistance to chemotherapy and radiation. This specific type of cancer is difficult to treat because the cancer stem cells that are not actively growing. These cells are dormant, which means they will not react to treatment because they are not dividing, and it is these cells that result in the high prevalence of relapse. Honokiol is a Chinese magnolia species that is known for its anti-inflammatory, anti-proliferative, and proapoptotic effects which make it an optimal candidate for glioma cell treatment. Honokiol was used in this experiment to treat U-87 glioblastoma cells in cell culture to compare to control U-87 cells that were not being treated with honokiol. Honokiol reduced the expression ofEGFR which along with an increase in Bax expression which promoted apoptosis amongst the cancer cells and inhibited tumor growth. Altogether, these results indicate that honokiol is an effective treatment for reducing tumorigenic potentials and will hopefully be useful in management of glioblastoma.
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Recommended Citation
Weaver, Julianne, "Honokoil Treatment on Glioblastoma Cells" (2021). Honors Theses. 911.
https://scholarlycommons.obu.edu/honors_theses/911