Loading s-hFGF1 in Polymeric Nanofiber Mats for Biomedical Applications

Date of Award

5-4-2021

Document Type

Thesis

Department

Biology

First Reader

Dr. Sharon Hamilton

Second Reader

Dr. Joe Jeffers

Third Reader

Dr. J. Scott Duvall

Abstract

The development of effective biocompatible modalities for wound healing purposes remains an area of intense research. The skin is the largest organ of the human body and carries out vital functions of homeostasis, such as serving as a protective barrier against the external environment, synthesizing vitamin D, facilitating the transfer of water, exchanging CO2, transmitting feedback of nerve endings to the brain, thermoregulation, etc (Torkaman, et al.). Considering the immense array of vital roles the skin carries out, it is imperative to continue advancing our biomedical innovations for whenever the skin is subjected to a substantial injury (Torkaman, et al.).

In recent years, the primary standard of care for severe and chronic wounds involves the utilization of wound dressings. These dressings are typically a type of gauze that acts as a replacement for the damaged tissues and implements a moisture-rich environment allowing for appropriate cell migration while decreasing scar tissue formation (Kordestani). Unfortunately, gauzes can cause secondary injuries when being removed from the wound site (Sun and Tan).

Comments

This thesis is currently embargoed.

Creative Commons License

Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

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