Title

Killing Breast Cancer One Porphyrin at a Time

Date of Award

2019

Document Type

Thesis

Department

Chemistry

First Advisor

Dr. Joseph Bradshaw

Second Advisor

Dr. Timothy Hayes

Third Advisor

Dr. Randall Wight

Abstract

New treatments for cancer are continuously being developed and improved. One such treatment is Photodynamic Therapy, more commonly referred to as PDT. PDT is quickly becoming more popular due to its relative lack of side effects that are present in other treatments. In PDT, light-sensitive agents are required and are activated by light in the targeted cells. There are many types of PDT agents but the one focused on in this research is a four-pyrrole ring structure known as a porphyrin. The combination of H2 TPPC with 3- amino-oxetane-3-yl-methanol created the final product ofH2TPP-Oxo-MeOH. Once the porphyrin was formed, it was then characterized using infrared spectroscopy (IR), UV -vis spectroscopy, and nuclear magnetic resonance (NMR). Its photocytotoxicity or its effect on cell death in triple-negative breast cancer cells, specifically MDA-MB-231, was tested using an MTT Assay with two conditions, dark and light.

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