Date of Award
2019
Document Type
Thesis
Department
Chemistry
First Reader
Dr. Joseph Bradshaw
Second Reader
Dr. Timothy Hayes
Third Reader
Dr. Randall Wight
Abstract
New treatments for cancer are continuously being developed and improved. One such treatment is Photodynamic Therapy, more commonly referred to as PDT. PDT is quickly becoming more popular due to its relative lack of side effects that are present in other treatments. In PDT, light-sensitive agents are required and are activated by light in the targeted cells. There are many types of PDT agents but the one focused on in this research is a four-pyrrole ring structure known as a porphyrin. The combination of H2 TPPC with 3- amino-oxetane-3-yl-methanol created the final product ofH2TPP-Oxo-MeOH. Once the porphyrin was formed, it was then characterized using infrared spectroscopy (IR), UV -vis spectroscopy, and nuclear magnetic resonance (NMR). Its photocytotoxicity or its effect on cell death in triple-negative breast cancer cells, specifically MDA-MB-231, was tested using an MTT Assay with two conditions, dark and light.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Lymburner, Taylor C., "Killing Breast Cancer One Porphyrin at a Time" (2019). Honors Theses. 719.
https://scholarlycommons.obu.edu/honors_theses/719
Included in
Alternative and Complementary Medicine Commons, Cancer Biology Commons, Chemistry Commons