Genomic Insight into Cardiac Adaptations: Analyzing Mouse Heart Tissue under Low Radiation and Low Gravity Conditions
Presentation Type
Thesis
Department
Biology
Location
Walker Conference Center C
Description
Prolonged spaceflight exposes astronauts to chronic irradiation and microgravity, inducing oxidative stress through reactive oxygen species (ROS). This study identified two significantly downregulated microRNAs, Mir6236 and Mir6240, in murine skeletal muscle following simulated space conditions. Sequencing and bioinformatics analysis revealed these microRNAs likely regulate key ROS-associated genes and pathways, including FN1, EZR, TRX2, and MAP2K1. Their dysregulation suggests a role in tumor progression and oxidative stress response. These findings underscore the need to further investigate microRNA-mediated gene regulation under space-like conditions to better understand the long-term health risks associated with extended space travel.
Creative Commons License
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Genomic Insight into Cardiac Adaptations: Analyzing Mouse Heart Tissue under Low Radiation and Low Gravity Conditions
Walker Conference Center C
Prolonged spaceflight exposes astronauts to chronic irradiation and microgravity, inducing oxidative stress through reactive oxygen species (ROS). This study identified two significantly downregulated microRNAs, Mir6236 and Mir6240, in murine skeletal muscle following simulated space conditions. Sequencing and bioinformatics analysis revealed these microRNAs likely regulate key ROS-associated genes and pathways, including FN1, EZR, TRX2, and MAP2K1. Their dysregulation suggests a role in tumor progression and oxidative stress response. These findings underscore the need to further investigate microRNA-mediated gene regulation under space-like conditions to better understand the long-term health risks associated with extended space travel.
Comments
The research for this presentation was done in cooperation with Dr. Nathan Reyna. This presentation is embargoed until May 2029.