Date of Award


Document Type




First Reader

Dr. Joseph Bradshaw

Second Reader

Dr. Nathan Reyna

Third Reader

Dr. Myra Houser


Photodynamic therapy (PDT) is a treatment modality for various illnesses, including some types of cancer. Lung cancer is the leading cause of cancer death in the United States. The prevalence of lung cancer in certain gender, racial, ethnic, and socioeconomic groups add to existing health disparities in the United States. For this reason, it is necessary to address the social determinants underlying lung cancer disparities, as well as improve treatment options. These treatment options should be cost effective, convenient, and increase survival rates. This research focused on synthesizing novel water-soluble porphyrin compounds for use as photosensitive agents in PDT for the treatment of lung cancer. Three novel water-soluble compounds were synthesized. The compounds were then purified and characterized prior to being tested on an A549 non-small cell lung cancer line in vitro.



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