Date of Award

Spring 2020

Document Type

Thesis

Department

Chemistry

First Reader

Dr. Joe Bradshaw

Second Reader

Dr. Angela Douglass

Third Reader

Dr. Allyson Phillips

Abstract

The applications of carbon nanomaterials (CNM), including graphene and its derivatives such as carbon nanotubes (CNTs) in nanomedicine is well established. These nanomaterials have been widely used as theranostic delivery systems with the potential to deliver bioactive agents and simultaneously detect selectively diseased tissues. A rather underexplored CNM for biomedical imaging and theranostics delivery are carbon nano-onions (CNOs). CNOs are carbon-based nanomaterials that can potentially be used in cancer therapy when they are functionalized. Recent studies on cellular fate of different CNMs, including CNOs, have demonstrated that the surface composition is critical for the in vivo application of these CNM. Current research discusses the preparation and characterization a novel CNO-Pt nanomaterial and the cell viability of U87 glioblastoma cells in the presence of this functionalized CNO. In order to form the desired CNO-Pt compound, the CNOs were first oxidized, followed by attachment of the cis-diammine platinum(II) dichloride. The novel CNO-Pt nanomaterial was characterized by IR and UV-Vis spectroscopies. Cytotoxicity of the material was tested on U87 glioblastoma cells. Following an Alamar Blue assay, the CNO-Pt material showed approximately 25% cell death at all concentrations after only 24 hours.

Included in

Oncology Commons

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.