Determining Toxicity of Bacterially-Produced Antibiotics
Date of Award
Dr. Ruth Plymale
Dr. Joseph Bradshaw
Dr. Randall Wight
Antibiotic-resistant bacteria are becoming a prevalent issue, making it pertinent that researchers discover new antibiotics to combat this. This research attempted to find viable antibiotics by determining the toxicity of secreted antibiotics from multiple bacteria and extracting antibiotics secreted from one bacterium. Twenty-seven antibiotic-producing bacteria were characterized during these experiments, an antibiotic extraction protocol was created, and the antibiotics produced from the bacterium were isolated using HPLC methods. After isolation, this antibiotic was tested for efficacy against pathogens, and it was found that the antibiotic still inhibited the growth of these bacteria, rendering the extraction and isolation process successful.
Clay, Logan, "Determining Toxicity of Bacterially-Produced Antibiotics" (2019). Honors Theses. 712.