Date of Award

Fall 1974

Document Type




First Reader



Solid phase peptide synthesis is a relatively new biochemical process for polymerization of amino acids. It involves the selection of amino acids, blocking groups, and resins. This procedure was first investigated by R. B. Merrifield in an attempt to simplify previous methods of peptide synthesis. Since other methods involved amino acids, peptide esters, and diketopiperazines, peptide synthesis had been limited by amino acid selection and a host of technical problems. Solid phase synthesis alleviates many of these difficulties and limitations by supplying a faster and simpler stepwise addition of a wide variety of naturally occurring and synthetically prepared amino acids to a solid resin support. The new process has opened new areas of biosynthesis as more study is made concerning proteins and polypeptides.



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