Date of Award


Document Type




First Reader

Dr. Collis R. Geren


The major hemorrhagic component of northern copperhead (Agkistrodon contortrix mokasen) venom was partially purified by ion exchange and molecular sieve column chromatography. TAME and Phospholipase enzymatic activities were shown to be unrelated to hemorrhage. BAEE and procoagulant activities appear to be associated. Hide powder activity seems to correlate with hemorrhagic activity. Both show metal and disulfide dependences.

The northern copperhead, (Agkistrodon contortrix mokasen) is commonly found in forests from Massachusetts to Illinois, and in highlands as far south as Georgia and Alabama.

The venom of the northern copperhead has been reported to contain several en- zymatic activities as well as a fraction which induces hemorrhage in mice. Whole venom was fractionated by carboxymethyl cellulose ion exchange chromatography into nine distinct fractions. The nonretained material was reported to contain the hemorrhagic activity.

This paper details work toward the separation and characterization of the major hemorrhagic component of northern copperhead venom.

Included in

Chemistry Commons



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