Date of Award

2015

Document Type

Thesis

Department

Biology

First Advisor

Dr. Lori Hensley

Second Advisor

Dr. Angela Douglass

Third Advisor

Dean Bryan McKinney

Abstract

Acute promyelocytic leukemia (APL) is a cancer that affects bone marrow, the blood-forming tissue (of the body). This type of leukemia accounts for approximately 10% of acute myeloid leukemia (AML) cases. Normally this cancer is treated with a drug called all-trans retinoic acid (ATRA), but other variations of treatment do exist. The importance of this research is that APL cells express contains a receptor, retinoic acid receptor-a (RARa), which ajulemic acid (AJA) may bind to in order to induce apoptosis in Ewing sarcoma (ES), a pediatric bone cancer. Therefore, this research will focus on the ability of AJA to induce the differentiation of APL cells, as ATRA does, thus demonstrating that AJA may be binding to RARa.

Included in

Diseases Commons

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